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No certain dose adjustment suggested when tofacitinib coadministered with powerful CYP2C19 inhibitors; lower tofacitinib dose if coadministered with both moderate CYP3A4 and potent CYP2C19 inhibitors .Modafinil appeared to make a concentration-associated suppression of CYP2C9 exercise, consequently suggesting prospective for CYP2C9 inhibition; caut
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